Onamia Region / Minnesota Lake Homes For Sale | Isle | 18 Listings
Your Isle MN Lake Home adventure starts now February 12, 2026. Explore all the active & coming soon lakefront listings.
Explore the Isle MN area and discover waterfront wonders on Mille Lacs Lake in the Onamia Region. Isle is nestled on the southeast shore of legendary Mille Lacs Lake, Minnesota's second largest inland lake at over 132,500 acres. Isle is a serene escape for lake home enthusiasts in the heart of the Onamia Region. This charming small town (population around 800) blends small town warmth with world class outdoor adventures, making it a top pick for families, anglers, and nature lovers seeking year round bliss. With crystal clear waters teeming with trophy walleye, muskie, northern pike, smallmouth bass, and perch, Isle offers direct access to prime fishing spots, boating launches, and sandy beaches that define "up north" living.